Natural Product Biosynthesis
Natural products with the potential to be used in drug therapy and for agricultural purposes, are a highly sought-after commodity. A famous historic example being penicillin, which has saved millions of lives. With the recent headline problems facing humanity – such as viral pandemics, antimicrobial resistance, food security, and ageing societies – there has never been a more important time to explore natural solutions to global problems.
We are specifically interested in the following areas:
Awakening "silent" biosynthetic gene clusters (BGCs) using Streptomyces and cell-free TX-TL expression
Development of Streptomyces venezuelae as a synthetic biology host
Studying enzyme function
Total enzyme biosynthesis